Browsing ETD -- Graduate theses by Title
Now showing items 751-770 of 1864
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GEL-FORMING EYE DROPS FOR ENHANCED INTRAOCULAR PRESSURE LOWERING FOR TREATMENT OF GLAUCOMA
(Johns Hopkins UniversityUSA, 2020-05-05)Glaucoma is one of the leading causes of blindness worldwide. Glaucoma develops as a result of an imbalance in aqueous humor production and drainage in the anterior chamber. Obstruction or blockage in the trabecular meshwork ... -
Gemcitabine Sensitivity on Podocalyxin Knockdown Pancreatic Cell Line SW1990
(Johns Hopkins University, 2014-12-01)In this study, we tested cell survival following treatments of Gemcitabine (GE) in scrambled control and Podocalyxin (PODXL) knockdown pancreatic cancer cell line SW1990. After testing several major chemotherapeutic drugs ... -
Gender Affirmation Therapy as Accommodation: Transitioning in a Nonideal Society Based on an Informed Consent Model
(Johns Hopkins UniversityUSA, 2021-08-11)Trans people who seek out Gender Affirming Therapies have historically met various barriers as they have gone through the process of transitioning. From restrictive diagnoses to unversed medical practitioners to misunderstandings ... -
Gender-Affirming Surgery: A Visual Resource for Patients, Relatives, and Healthcare Providers
(Johns Hopkins UniversityUSA, 2018-03-22)Gender dysphoria occurs when an individual’s psychological identity as a male or female conflicts with their biological sexual characteristics, resulting in anxiety, depression, and distress. Transgender individuals often ... -
Gene Expression Analysis of Cellular Changes in Response to Fibroblast Injection and Wounding
(Johns Hopkins UniversityUSA, 2021-04-15)Within the United States, there are over two million individuals who have undergone amputations with an additional 185,000 receiving amputations each year (Yang et al., 2012). Amongst the amputee population, 48.2% of ... -
Generating synthetic Gadolinium-Enhanced T1-weighted (Gd-T1w) MRI
(Johns Hopkins UniversityUSA, 2020-06-26)Gadolinium-enhanced T1-weighted (Gd-T1w) Magnetic Resonance Imaging (MRI) is a standard MRI pulse sequence used in diagnosing, evaluating, and treating patients suffering from cancer such as glioma. However, the injection of ... -
Generation of an H3N2 Influenza A Reporter Virus to Visualize Modern Infection Dynamics
(Johns Hopkins UniversityUSA, 2018-04-25)The public health burden of influenza is exacerbated by the continuous emergence of new strains and unanswered questions about viral spread within the host. Previously, groups have utilized reporter viruses encoding ... -
GENETIC CHARACTERIZATION OF A MOUSE MODEL FOR ALS
(Johns Hopkins UniversityUSA, 2020-08-28)Amyotrophic lateral sclerosis (ALS) is a debilitating neurodegenerative disease characterized by deteriorating motor neurons in the muscles and corticospinal tract. The progression of the disease has yet to be elucidated, ... -
Genetic Counselor Tailoring of Information about Genetic Conditions to Children and Adolescents
(Johns Hopkins UniversityUSA, 2021-12-15)There is growing literature demonstrating the importance of effective and tailored healthcare communication with children and adolescents. This study aimed to understand how genetic counselors tailor their language and ... -
Genetic Counselors' Implicit Racial Bias and Cognitive, Emotional, and Informational Exchange in Simulated Sessions
(Johns Hopkins UniversityUSA, 2018-12-21)Objectives: Implicit racial bias has been shown to negatively affect several communication processes (Schaa et al., 2015), suggesting that bias is detrimental to the genetic counselor-client relationship and therefore ... -
Genetic Diversity of Rickettsia parkeri in sympatric tick populations at a focal site in northern Virginia: Implications for pathogen dispersal and spotted fever group rickettsiosis.
(Johns Hopkins University, 2015-04-22)Rickettsia parkeri is emerging as a tick-borne pathogen of public health importance, particularly for its previously unrecognized role as a potential pathogen responsible for rapidly increasing cases of spotted fever group ... -
Genetic susceptibility to chronic inflammatory intestinal diseases and risk of pancreatic ductal adenocarcinoma: a pathway-based analysis of genome-wide association studies
(Johns Hopkins UniversityUSA, 2018-04-25)Background: Chronic inflammation is known to play a role in pancreatic carcinogenesis. Registry-based epidemiologic studies suggest associations between chronic inflammatory intestinal diseases and pancreatic ductal ... -
Genetic Testing Preferences and Intentions in Patients with Clinically Diagnosed Familial Hypercholesterolemia
(Johns Hopkins UniversityUSA, 2017-12-18)Purpose Familial Hypercholesterolemia (FH) is a common (1/250) Mendelian disorders that results in elevated LDL cholesterol levels from birth, and if left untreated can result in premature heart disease. Only up to 10% of ... -
GENETICAL DETERMINANTS OF ZINC UPTAKE ASSOCIATED WITH CITROBACTER RODENTIUM PATHOGENESIS
(Johns Hopkins UniversityUSA, 2021-05-06)The human enteric pathogens Enteropathogenic Escherichia coli (EPEC) and Enterohemorrhagic E. coli (EHEC) are A/E pathogens that colonize in human gastrointestinal mucosa and cause foodborne diseases worldwide. Citrobacter ... -
Genetically Encoded Calcium Indicator Illuminates Calcium Dynamics In Primary Cilia
(Johns Hopkins University, 2014-04-21)The primary cilium is an extraordinary, hair-like structure that extends outward from the plasma membrane of cells. Ubiquitous to almost every cell type in the human body, this singular, immotile structure, serves as an ... -
Genetics Researchers’ Perceived Obligations to Return Incidental Findings and Individual Research Results to Participants
(Johns Hopkins University, 2015-01-30)Background: Clinical investigators are increasingly facing decisions about returning individual research results (IRRs) and incidental findings (IFs) from genome sequencing to research participants. Studies have shown that ... -
Genome-scale model-based feed-forward control of C. vulgaris improves efficiency of nitrate supplied to a fed-batch culture
(Johns Hopkins UniversityUSA, 2018-07-31)Microalgae are widely recognized as promising biofuel feedstock due to their, short harvesting cycle, high photosynthetic efficiency, and high energy density. Lowering the production cost of algal-derived biofuels is ... -
Geometrically projected discrete dislocation dynamics
(Johns Hopkins UniversityUSA, 2016-08-15)Plastic deformation of crystalline materials is due to the motion of large numbers of dislocations, which are line defects in the crystal’s atomic structure. Various macroscopic properties of deformed crystalline solids ... -
Gerrymandering - A Threat to the Republic
(Johns Hopkins UniversityUSA, 2020-05-14)This thesis explores the relationship between the concept of gerrymandering and the destruction of social trust. The first chapter discusses the history of gerrymandering in the United States. The second chapter examines ... -
Global Sensitivity Analysis for Randomized Trials with Informative Assessment Times: A Fully Parametric Approach
(Johns Hopkins UniversityUSA, 2020-04-30)Many randomized trials are designed to collect outcomes at fixed points in times after randomized. In practice, study participants miss their assessments or are assessed off-schedule. If and when individuals are assessed ...