Browsing ETD -- Graduate theses by Title
Now showing items 835-854 of 1864
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Identification and comparison of imputed and genotyped variants for genome-wide association study of orofacial cleft case-parent trios
(Johns Hopkins UniversityUSA, 2019-04-26)Background: Orofacial clefts (OFCs) – cleft lip with/without cleft palate (CL/P) and cleft palate (CP) – are the most common craniofacial malformations among newborns. Both CL/P and CP show strong familial aggregation ... -
Identification of a Global Aneuploidy-Associated Transcriptional and Phenotypic Signature in Budding Yeast
(Johns Hopkins UniversityUSA, 2017-05-02)Aneuploidy, an unbalanced genome state with either gain or loss of chromosomes, is known to have dramatic effects on cellular physiology, ranging from detrimental effects including genetic disorders such as Down Syndrome ... -
IDENTIFICATION OF A NOVEL HIF INHIBITOR IN HEPATOCELLULAR CARCINOMA
(Johns Hopkins UniversityUSA, 2022-05-03)A major obstacle in the discovery of effective cancer therapeutics is the heterogenous tumor microenvironment. The unique oncogenic profiles of tumor microenvironments can severely alter the biological activity of compounds ... -
IDENTIFICATION OF INPUTS FOR A QUANTITATIVE MICROBIAL RISK ASSESSMENT OF VIBRIO PARAHAEMOLYTICUS IN CHESAPEAKE BAY AND WASHINGTON STATE
(Johns Hopkins UniversityUSA, 2019-04-23)Background / Introduction: Non-cholera Vibrio bacteria are a major cause of foodborne illness in the United States. Raw oyster consumption is increasingly implicated in gastroenteritis caused by pathogenic strains of ... -
Identification of Novel F-Box Proteins that Regulate Caenorhabditis elegans Synapsis
(Johns Hopkins UniversityUSA, 2022-04-15)Meiosis is a specialized type of cell division that lays the foundation of propagation for all sexually reproducing lifeforms. During meiotic prophase, a proteinaceous structure called the synaptonemal complex (SC) assembles ... -
IDENTIFICATION OF PRIMARY TIME DRIVERS IN COMPLIANCE FOR NON-MEDICAL STEM RESEARCH, AND BEST PRACTICES FOR REDUCING TIME INVESTMENT BY FACULTY
(Johns Hopkins UniversityUSA, 2019-08-05)An increase in time commitment for compliance measures in STEM research has been measured by the 2018 Federal Demonstration Partnership Survey (Schneider, 2019), despite widespread use of submission and signature technology, ... -
Identification of Prognostic Baseline Variables to Be Used in the Analysis of Alzheimer’s Disease and Mild Cognitive Impairment Clinical Trials
(Johns Hopkins UniversityUSA, 2021-05-05)Adjusting for baseline variables that are prognostic for the outcome can improve precision of estimated marginal treatment effects in randomized trials, thus improving power for a fixed sample size or reducing the required ... -
IDENTIFICATION OF SOURCES OF POLLUTANTS IN BALTIMORE HARBOR
(Johns Hopkins University, 2014-05-09)Nutrient and sediment pollution are important issues in Baltimore Harbor. The poor water quality has affected human activities and lives in the Harbor. This report applied Chesapeake Bay Phase 5.3 Watershed Model output ... -
Identification of the Roles of the Small Ubiquitin-Related Modifier (SUMO) in Cellular Stress Response
(Johns Hopkins University, 2015-04-10)Proper protein folding is essential for cell function, as misfolding leads to cell stress and cytotoxicity. Misfolded proteins are associated with several serious diseases in humans such as Parkinson’s and Alzheimer’s ... -
IDENTIFICATION OF U6 PROMOTERS FOR CRISPR-CAS9 GENOME ENGINEERING IN AEDES AEGYPTI
(Johns Hopkins UniversityUSA, 2018-04-25)Aedes aegypti is the primary vector of Zika and Dengue viruses. The objective of this study was to identify a functional U6 snRNA promoter for plasmid-based sgRNA expression and CRISPR-Cas9 genome engineering in Ae. aegypti. ... -
IDENTIFYING APPLICATIONS OF ARTIFICIAL INTELLIGENCE TO SUPPORT PRE-AWARD ACTIVITIES IN UNIVERSITY RESEARCH ADMINISTRATION
(Johns Hopkins UniversityUSA, 2020-04-07)A thriving research enterprise depends on investigators securing sponsored program funding. In the university setting, research administrators support investigators with resources to locate awards and write compelling ... -
Identifying RNA-binding Proteins Required for mRNA localization to Drosophila Germ Granules
(Johns Hopkins UniversityUSA, 2021-04-15)Germ cells are specialized cells in metazoans that transfer genetic material from parents to the offspring, thus allowing the continuation of the species. In Drosophila, a specialized cytoplasm called the germ plasm ... -
IDENTIFYING SIGNALS OF ICU READMISSIONS AND POST-DISCHARGE MORTALITY FROM PHYSIOLOGICAL TIME SERIES DATA USING MACHINE LEARNING
(Johns Hopkins UniversityUSA, 2021-08-11)Rationale Critical care utilization and costs are a vast part of our healthcare system and continue to grow. One opportunity for increasing the quality and efficiency of critical care is reducing intensive care unit (ICU) ... -
Identifying Technology(ies) for clinical research post COVID-19
(Johns Hopkins UniversityUSA, 2020-12-17)Clinical research aims to understand diagnostic methods, diseases, and new treatments or medical devices that can advance patient care. The COVID-19 pandemic in 2020, a respiratory disease caused by SARS-CoV-2, impacted ... -
IDENTIFYING THE COMMON BARRIERS OF PATIENT RECRUITMENT AND RETENTION OF WOMEN IN HIV/AIDS CLINICAL TRIALS TO DETERMINE THE BEST PRACTICES IN MINIMIZING UNDER-ENROLLMENT AND WITHDRAWS FROM CLINICAL STUDIES
(Johns Hopkins UniversityUSA, 2020-05-05)Purpose: Many past human immunodeficiency virus (HIV) clinical trials have struggled to recruit and retain female participants due to their encounters with potential barriers that prevented the participants’ initial or ... -
IDENTIFYING THE ROLE OF NATURAL KILLER CELLS AND CD8+CD11C+ T CELLS INDUCED BY A DENDRITIC CELL TARGETING VACCINE IN COMBINATION WITH IFNA AND 5-AZA2’DEOXYCYTIDINE IN THE B16F10 MELANOMA MODEL
(Johns Hopkins UniversityUSA, 2022-04-25)This study investigates the cellular immune response elicited by a DNA vaccine designed to slow progression of melanomas in a mouse model system. In this vaccine formulation, the melanoma antigens Gp10025-235 and Trp2170-269 ... -
Identifying the Substrate Specificities of SENP1 and SENP2 in Recognition of Sumoylated Thymine-DNA Glycosylase
(Johns Hopkins UniversityUSA, 2018-04-26)SUMO is an essential post-translational protein modification regulated in part by the activity of a family of SUMO-specific proteases known as SENPs. Mammalian cells express six different SENPs with essential and non-redundant ... -
IF LOOKS COULD KILL, BANS ON PHYSICAL FEATURES OF ASSAULT STYLE WEAPONS: CONTRIBUTION TO FIREARM AND GUN VIOLENCE SAFETY OR VIOLATION OF THE SECOND AMENDMENT?
(Johns Hopkins UniversityUSA, 2020-01-22)The number of mass shootings with assault rifles, such as AR-15’s, continue to make headlines, fuel public concern over gun violence, and spur elected officials to find solutions for what remains a highly divisive issue ... -
ILLNESS IDENTITY AND PSYCHOLOGICAL ADAPTATION IN INDIVIDUALS WITH HYPERMOBILE EHLERS DANLOS SYNDROME OR HYPERMOBILITY SPECTRUM DISORDER
(Johns Hopkins UniversityUSA, 2020-03-10)Background: Much of the research literature in the hEDS and HSD populations focuses on diagnostic classification and quantifying patients’ physical and psychological functioning. Little is known about the psychological ... -
Illustrations for Health Assessment Techniques of the Atlantic Horseshoe Crab, Limulus polyphemus
(Johns Hopkins UniversityUSA, 2017-03-22)The Atlantic horseshoe crab, Limulus polyphemus, is a “living fossil” extant for over 340 million years (Shuster et al. 2003) and is very important for conservation and medical research. The dense egg production during ...