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EFFECT OF INTEGRIN α5 ON CANCER CELL MOTILITY IN 2D AND 3D MATRICES
(Johns Hopkins University, 2015-07-01)
The main cause of cancer related deaths is results from metastasis of cancer, or the spread of cancer to secondary sites. In order to metastasize, cancer cell migration is necessary. Numerous studies in cancer biology have ...
The Role of MAP3K1 in Luminal Subtype Breast Cancer
(Johns Hopkins University, 2016-06-14)
Mitogen-activated protein kinase kinase kinase 1, or MAP3K1, has been shown in a number of studies to be associated with luminal A subtypes of breast cancer. However, in the absence of any functional studies, whether this ...
FUNCTIONAL ANALYSIS OF TYROSINE KINASE MUTANTS IN CANCER
(Johns Hopkins University, 2016-08-15)
Cancer or uncontrolled cell division which can invade into other tissues is today among the leading causes of morbidity and mortality worldwide. Genomic alterations in protein coding genes are a major feature of cancerous ...
Nuclear Keratin 17 and its role in the DNA Damage Response
(Johns Hopkins University, 2017-06-23)
Keratin 17 (Krt17; K17) is an intermediate filament protein known to be robustly upregulated in many types of epithelial-derived tumors. Recently, we have reported that K17 is capable of localizing to the nucleus of ...
Phenotypic Signatures and Molecular Mechanisms of Cancer Cell Invasion
The leading cause of cancer-related deaths is when cancer progresses to the metastatic stage, spreading into secondary sites. In order to combat metastasis, emerging research in cancer biology examines signaling pathways ...
Pneumatic Delivery of Untethered Micro-Surgical Tools
Colorectal cancer is an extremely prevalent disease within the US with high morbidity rates, which can be significantly reduced with early detection and early treatment. However, many patients are hesitant to get regular ...