4D Image Reconstruction with Dual Respiratory and Cardiac Motion Correction for Cardiac PET

dc.contributor.advisorTsui, Benjamin M. W.
dc.contributor.committeeMemberXu, Jingyan
dc.contributor.committeeMemberGoutsias, John I.
dc.contributor.committeeMemberTran, Trac Duy
dc.creatorFeng, Tao
dc.date.accessioned2018-05-22T04:01:25Z
dc.date.available2018-05-22T04:01:25Z
dc.date.created2015-12
dc.date.issued2015-10-23
dc.date.submittedDecember 2015
dc.date.updated2018-05-22T04:01:25Z
dc.description.abstract4D image reconstruction with motion correction is the solution to improve image quality and resolution degraded by respiratory motion (RM) and cardiac motion (CM) in cardiac PET scans. The improved image quality can potentially improve clinical diagnosis, and can be traded for reduced injected radiation dose or reduced imaging time for improving patient comfort. There are three steps for 4D image reconstruction with motion correction: 1) 4D data generation (gating), 2) 4D respiratory and cardiac (R&C) motion estimation, and 3) 4D R&C motion correction. We have developed and evaluated multiple methods for each step including (step 1) data-driven gating, MRI-navigator-gating, (step 2) 4 different methods for dual R&C motion estimation after reconstruction (MEAR), CM estimation during reconstruction (MEDR), RM estimation before reconstruction (MEBR), and (step 3) dual R&C motion correction after (MCAR), during (MCDR), and before (MCBR) image reconstruction. Realistic Monte Carlo simulated 4D cardiac PET data using the 4D XCAT phantom and accurate models of the scanner design parameters and performance characteristics and clinical patient data were used to evaluate all different methods. Data-driven gating method was shown to provide robust gating results in high myocardium uptake situations while MRI-navigator based gating showed better results in low myocardium uptake situations. Separate R&C MEAR with modeling of RM on CM estimation was shown to be the best option for accurate estimation of dual R&C motion estimation. The MCDR method yields the best performance for different noise situations for both patient and simulation, while MCBR reduces computational time dramatically but the resultant 4D cardiac gated PET images has overall inferior image quality when compared to that from the MCAR and MCDR approaches in the ‘almost’ noise free case. Also, the MCBR method has better noise handling properties when compared with MCAR and provides better quantitative result in high noise cases. In general, our developed methods demonstrated the importance of motion correction on image qualities, our work also provide a general guideline for different applications that requires either highly quantitative data or qualitative images. Our works also provide practical means for applying 4D image reconstruction with reasonable computational cost.
dc.format.mimetypeapplication/pdf
dc.identifier.urihttp://jhir.library.jhu.edu/handle/1774.2/58757
dc.languageen
dc.publisherJohns Hopkins University
dc.publisher.countryUSA
dc.subjectMotion correction, PET.
dc.title4D Image Reconstruction with Dual Respiratory and Cardiac Motion Correction for Cardiac PET
dc.typeThesis
dc.type.materialtext
thesis.degree.departmentElectrical and Computer Engineering
thesis.degree.disciplineElectrical Engineering
thesis.degree.grantorJohns Hopkins University
thesis.degree.grantorWhiting School of Engineering
thesis.degree.levelDoctoral
thesis.degree.namePh.D.
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