19F MRI Tracking of Inflammation for Earlier Prediction of Colitis-Associated Cancer

dc.contributor.advisorWalczak, Piotr
dc.contributor.committeeMemberBulte, Jeff W. M.
dc.contributor.committeeMemberJanowski, Miroslaw
dc.creatorShin, Soo Hyun
dc.date.accessioned2016-12-15T06:24:02Z
dc.date.available2016-12-15T06:24:02Z
dc.date.created2014-05
dc.date.issued2014-05-01
dc.date.submittedMay 2014
dc.date.updated2016-12-15T06:24:02Z
dc.description.abstractColitis-associated cancer (CAC) develops through complication of inflammatory bowel diseases (IBD) such as ulcerative colitis (UC) and Crohn’s disease (CD). Currently, CACs can only be diagnosed by colonoscopy and biopsy, which are invasive and prone to sampling errors. In this study, the feasibility of using 19F MRI for earlier diagnosis of CAC development was investigated by serial imaging of inflammatory sites in the colon. In vivo MR imaging of CAC-induced mice showed patchy distributions of 19F signals on colon wall, and co-localization of 19F signal patches with dysplastic and inflammatory lesions were confirmed by ex vivo imaging. Histological scores of inflammation and dysplasia showed significant correlation with the intensity of 19F signals. Overall, 19F MRI was used for the first time to observe the early stage of carcinomatous change of inflammatory sites in the colon, which is expected to enable earlier diagnosis of CAC. Thewell established relationship between inflammation and cancer suggests that 19F MRI can also be used in early diagnosis of wide range of cancer types.
dc.format.mimetypeapplication/pdf
dc.identifier.urihttp://jhir.library.jhu.edu/handle/1774.2/39240
dc.languageen
dc.publisherJohns Hopkins University
dc.publisher.countryUSA
dc.subjectInflammatory bowel diseases
dc.subject19F MRI
dc.title19F MRI Tracking of Inflammation for Earlier Prediction of Colitis-Associated Cancer
dc.typeThesis
dc.type.materialtext
thesis.degree.departmentBiomedical Engineering
thesis.degree.disciplineBiomedical Engineering
thesis.degree.grantorJohns Hopkins University
thesis.degree.grantorWhiting School of Engineering
thesis.degree.levelMasters
thesis.degree.nameM.S.E.
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