Exploring HIV disease indicators at MDR-TB treatment initiation in South Africa

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2025-01-01
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International Union Against Tuberculosis and Lung Disease
Abstract
<jats:p><jats:bold>BACKGROUND:</jats:bold> Understanding relationships between HIV and multidrug-resistant TB (MDR-TB) is crucial for ensuring successful MDR-TB outcomes.<jats:bold>METHODS:</jats:bold> We used a cross-sectional analysis to evaluate sociodemographic and clinical characteristics as correlates of antiretroviral therapy (ART) use, having an HIV viral load (VL) result, and HIV viral suppression in a cross-sectional sample of people with HIV (PWH) and MDR-TB enrolled in a cluster-randomized trial of nurse case management to improve MDR-TB outcomes.<jats:bold>RESULTS:</jats:bold> Among 1,479 PWH, the mean age was 37.1 years; 809 (54.7%) were male, and 881 (59.6%) were taking ART. Housing location, employment status, and CD4 count differed significantly between those taking vs. those not taking ART. Among the 881 taking ART, 681 (77.3%) had available HIV VL results. Housing location, CD4 count, and prior history of TB differed significantly between those with and without a VL result. Among the 681 with a VL result, 418 (61.4%) were virally suppressed. Age, education level, CD4 count, TB history, housing location, and ART type differed significantly between those with and without viral suppression.<jats:bold>CONCLUSION:</jats:bold> PWH presenting for MDR-TB treatment with a history of TB, taking a protease inhibitor, or living in a township may risk poor MDR-TB outcomes.</jats:p>
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K. Geiger, A. Patil, A. Bergman, et al. (2024-1-1). "Exploring HIV disease indicators at MDR-TB treatment initiation in South Africa." The International Journal of Tuberculosis and Lung Disease. 28 (1). 10.5588/ijtld.23.0242.