Cost-effective therapeutic hypothermia treatment device for hypoxic ischemic encephalopathy

dc.contributor.authorKim, John J.
dc.contributor.authorBuchbinder, Nathan
dc.contributor.authorAmmanuel, Simon
dc.contributor.authorKim, Robert
dc.contributor.authorMoore, Erika
dc.contributor.authorO’Donnell, Neil
dc.contributor.authorLee, Jennifer K.
dc.contributor.authorKulikowicz, Ewa
dc.contributor.authorAcharya, Soumyadipta
dc.contributor.authorAllen, Robert H.
dc.contributor.authorLee, Ryan W.
dc.contributor.authorJohnston, Michael V.
dc.description.abstractDespite recent advances in neonatal care and monitoring, asphyxia globally accounts for 23% of the 4 million annual deaths of newborns, and leads to hypoxic-ischemic encephalopathy (HIE). Occurring in five of 1000 live-born infants globally and even more in developing countries, HIE is a serious problem that causes death in 25%–50% of affected neonates and neurological disability to at least 25% of survivors. In order to prevent the damage caused by HIE, our invention provides an effective whole-body cooling of the neonates by utilizing evaporation and an endothermic reaction. Our device is composed of basic electronics, clay pots, sand, and urea-based instant cold pack powder. A larger clay pot, lined with nearly 5 cm of sand, contains a smaller pot, where the neonate will be placed for therapeutic treatment. When the sand is mixed with instant cold pack urea powder and wetted with water, the device can extract heat from inside to outside and maintain the inner pot at 17°C for more than 24 hours with monitoring by LED lights and thermistors. Using a piglet model, we confirmed that our device fits the specific parameters of therapeutic hypothermia, lowering the body temperature to 33.5°C with a 1°C margin of error. After the therapeutic hypothermia treatment, warming is regulated by adjusting the amount of water added and the location of baby inside the device. Our invention uniquely limits the amount of electricity required to power and operate the device compared with current expensive and high-tech devices available in the United States. Our device costs a maximum of 40 dollars and is simple enough to be used in neonatal intensive care units in developing countries.en_US
dc.description.sponsorshipJH Libraries Open Access Funden_US
dc.identifier.citationdoi: 10.2147/MDER.S39254en_US
dc.publisherDove Pressen_US
dc.relation.ispartofseriesMedical Devices: Evidence and Research;vol. 6 p. 1–10 2013
dc.subjectTherapeutic Hypothermiaen_US
dc.subjectEvaporative Coolingen_US
dc.subjectHypoxic Ischemic Encephalopathyen_US
dc.subjectBirth Asphyxiaen_US
dc.titleCost-effective therapeutic hypothermia treatment device for hypoxic ischemic encephalopathyen_US
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
2012 Kim Cost Effective therapeutic.pdf
2.11 MB
Adobe Portable Document Format
Research Article
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
2.81 KB
Item-specific license agreed upon to submission