JScholarship: Recent submissions
Now showing items 21-40 of 57069
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METAPLASTICITY IN A MOUSE MODEL OF ALZHEIMER’S DISEASE AND POSSIBLE THERAPEUTIC INTERVENTIONS
(Johns Hopkins UniversityUSA, 2014-09-15)Alzheimer’s disease (AD) is a progressive neurodegenerative disorder, causing loss of synaptic contacts and cognitive decline. It is widely believed that AD is initiated by synaptic dysfunction caused by production of Aβ ... -
Gender, Tyranny, and Republicanism in England, 1603-1660
(Johns Hopkins UniversityUSA, 2014-08-26)This dissertation examines how classical history and gendered conceptions of masculine governance and misgovernance shaped the political culture of seventeenth-century England, the distinctive character of English republican ... -
“SOLEMN PROGRESS”: MODERNISM, SOCIAL CONSTITUTION, AND COSMIC LIFE
(Johns Hopkins UniversityUSA, 2014-08-25)This dissertation examines how modernist writers engaged with various forms of civic virtue even as they considered how still broader affective investments might sustain a common humanity. Employing a method similar to ... -
Theoretical study of the rotationally and vibrationally inelastic collision dynamics of small molecules
(Johns Hopkins UniversityUSA, 2014-08-21)Rotationally and vibrationally inelastic collision dynamics of several small molecules are investigated through ab initio calculations of potential energy surfaces (PESs) and time-independent close-coupling scattering ... -
Cell cycle regulation during mammalian female meiosis: Characterization of the MASTL-ENSA/ARPP19 pathway in mouse oocytes
(Johns Hopkins UniversityUSA, 2014-08-13)Mammalian oocytes undergo two successive rounds of division without an intervening S-phase to form a haploid gamete. Oocytes are arrested in prophase I in the ovary until the time of ovulation when the oocyte exits from ... -
Novel Approaches to Studying BRCA Variants of Unknown Clinical Significance
(Johns Hopkins UniversityUSA, 2014-08-12)Hereditary breast cancer comprises ~7% of the annual breast cancer cases in the United States. The two genes suspected in the majority of cases are the breast and ovarian cancer susceptibility genes 1 and 2 (BRCA1 and ... -
MOLECULAR MECHANISMS REGULATING COPPER BALANCE IN HUMAN CELLS
(Johns Hopkins UniversityUSA, 2014-08-07)Precise copper balance is essential for normal growth, differentiation, and function of human cells. Loss of copper homeostasis is associated with heart hypertrophy, liver failure, neuronal de-myelination and other ... -
CONSUMPTION OF SUGAR-SWEETENED BEVERAGES AMONG CALIFORNIA ADULTS: ROLE OF NEIGHBORHOOD ETHNIC DENSITY, ACCULTURATION, AND DISPARITIES
(Johns Hopkins UniversityUSA, 2014-07-31)This dissertation aims to explore whether ethnic disparities exist with sugar-sweetened beverages (SSBs) consumption among adults living in California, and to explore how acculturation and neighborhood ethnic density are ... -
Natural killer cells suppress cardiac inflammation and fibrosis by inhibiting eosinophil accumulation
(Johns Hopkins UniversityUSA, 2014-07-30)Myocarditis is the inflammation of the cardiac muscle and a leading cause of sudden cardiac failure. Previously, our lab has shown that natural killer (NK) cells suppress group B coxsackievirus (CVB) and mouse cytomegalovirus ... -
Summer Learning in the City: How Schools, Families, and Neighborhoods Influence Urban Elementary School Students' Opportunities and Achievements
(Johns Hopkins UniversityUSA, 2014-08-15)It has been well documented that educational inequality grows during the summer months. While this much is clear, researchers, policymakers, and practitioners seek deeper understandings of why low-income children tend to ... -
Pancreatic Progenitor Cells in Mice
(Johns Hopkins UniversityUSA, 2014-07-25)We generated a novel transgenic mouse expressing a tdTomato fluorophore, as well as a Strep/Flag-tagged version of Ptf1a from the native Ptf1a locus. I crossed this mouse line with the well-characterized Pdx1-GFP mouse, ... -
Show Me How to Get There: The Rule of Law as a Language Game
(Johns Hopkins UniversityUSA, 2014-07-25)This dissertation is about the relationship between legal consistency and the rule of law. Chapter 1 begins the dissertation with four prefatory points central to exploring this relationship. Chapter 2 then surveys how ... -
Contextualizing the 'Inner' Pretense and Aspect in Wittgenstein, Lohenstein, and Goethe
(Johns Hopkins UniversityUSA, 2014-07-24)Pretense, or the opposite of sincerity, is the mismatch between the ‘inner’ and the ‘outer.’ This assertion is among the most effective and far-reaching conceptual shifts with which the Enlightenment marked its discontinuity ... -
Essays on Deposit Insurance, Underground Banking and Buying Local Preference
(Johns Hopkins UniversityUSA, 2014-07-25)This dissertation consists of three self-contained essays that explore three distinct topics in deposit insurance, underground banking and social preference respectively. The first essay, "Deposit Insurance, Market ... -
KOREAN DIETARY PATTERNS AND THE PREVALENCE OF DIABETES, METABOLIC SYNDROME, AND SUBCLINICAL ATHEROSCLEROSIS
(Johns Hopkins UniversityUSA, 2014-07-23)This dissertation investigates the associations between dietary patterns, diabetes, metabolic syndrome, and subclinical atherosclerosis. The literature on Asian dietary patterns and cardiovascular health is limited. For ... -
Essays on Macroeconomics and Finance
(Johns Hopkins UniversityUSA, 2014-07-28)This dissertation consists of three chapters. In Chapter 1, I study an asset pricing implication of a New Keynesian model. Quantitative New Keynesian models have strong implications for the joint variation of total wealth, ... -
Bawdy City: Commercial Sex, Capitalism, and Regulation in Nineteenth-Century Baltimore
(Johns Hopkins UniversityUSA, 2014-07-16)This dissertation examines the development and policing of Baltimore’s commercial sex trade between 1800 and 1880. Using a core source base of Baltimore City court dockets, newspaper and census records, estate inventories, ... -
THE ROLE OF MESENCHYMAL STEM CELLS ON EFFECTOR CD8+ T CELL DEVELOPMENT AND NEUROINFLAMMATORY AUTOIMMUNE DISEASE
(Johns Hopkins UniversityUSA, 2014-07-02)Mesenchymal stem cells (MSCs) have emerged as a promising candidate for inflammatory modulation and disease amelioration, especially of neuro-inflammatory diseases such as multiple sclerosis (MS). Auto-reactive CD4+ and ... -
Civic Economies: Commerce, Regulation, and Public Space in the Antebellum City
(Johns Hopkins UniversityUSA, 2014-07-17)Between 1790 and 1860, the governance of Baltimore and Philadelphia transformed to meet the demands of a capitalist economy predicated on moving people and goods ever more rapidly and indiscriminately. Far from being an ... -
'Deprived of Their Liberty': Enemy Prisoners and the Culture of War in Revolutionary America, 1775-1783
(Johns Hopkins UniversityUSA, 2014-06-24)Deprived of Their Liberty explores Americans' changing conceptions of legitimate wartime violence by analyzing how the revolutionaries treated their captured enemies, and by asking what their treatment can tell us about ...