EVALUATION OF THE PROTECTIVE EFFICACY OF HIV-1 PROTEASE INHIBITORS AGAINST ENTEROVIRUS 71 INFECTION IN VITRO
| dc.contributor.advisor | Yu, Xiao-Fang | en_US |
| dc.contributor.author | Kurapati, Sravya | en_US |
| dc.contributor.committeeMember | Markham, Richard B. | en_US |
| dc.date.accessioned | 2015-02-11T04:17:13Z | |
| dc.date.available | 2015-02-11T04:17:13Z | |
| dc.date.created | 2014-05 | en_US |
| dc.date.issued | 2014-04-26 | en_US |
| dc.date.submitted | May 2014 | en_US |
| dc.description.abstract | Enterovirus associated hand, foot and mouth disease continues to be a prominent public health issue despite the numerous vaccine trials and drug development attempts. The lack of a specific and protective antiviral drug has made disease management extremely challenging and gravely underscores the need for effective therapy options. Nelfinavir, belonging to the HIV-1 protease inhibitors, was found to have significant antiviral activity compared to other HIV-1 protease inhibitors. With a low cytotoxicity and high inhibitory action against both the BrCr and H strain of EV71, nelfinavir exhibited potential broad spectrum antiviral properties. Additionally, its ability to impede the virus irrespective of the stage of the infection makes it a more promising therapeutic option. The data strongly support the potential usefulness of nelfinavir as a broad spectrum antiviral drug with significant protective efficacy against EV71 infection in vitro. | en_US |
| dc.format.mimetype | application/pdf | en_US |
| dc.identifier.uri | http://jhir.library.jhu.edu/handle/1774.2/37284 | |
| dc.language | en | |
| dc.publisher | Johns Hopkins University | |
| dc.subject | Enterovirus 71 | en_US |
| dc.subject | Hand foot and mouth disease | en_US |
| dc.subject | HIV-1 protease inhibitors | en_US |
| dc.subject | antiviral | en_US |
| dc.subject | drug | en_US |
| dc.subject | in vitro | en_US |
| dc.title | EVALUATION OF THE PROTECTIVE EFFICACY OF HIV-1 PROTEASE INHIBITORS AGAINST ENTEROVIRUS 71 INFECTION IN VITRO | en_US |
| dc.type | Thesis | en_US |
| dc.type.material | text | en_US |
| thesis.degree.department | Molecular Microbiology and Immunology | en_US |
| thesis.degree.discipline | not listed | en_US |
| thesis.degree.grantor | Johns Hopkins University | en_US |
| thesis.degree.grantor | Bloomberg School of Public Health | en_US |
| thesis.degree.level | Masters | en_US |
| thesis.degree.name | Sc.M. | en_US |
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