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Constitutively active ESR1 mutations in gynecologic malignancies and clinical response to estrogen-receptor directed therapies
OBJECTIVE: Endocrine therapy is often considered as a treatment for hormone-responsive gynecologic malignancies. In breast cancer, activating mutations in the estrogen receptor (mutESR1) contribute to therapeutic resistance ... -
Electronic Research Administration (ERA) Systems and Pre-Award Grants Management: A Review of MU-JHU Care Limited Pre-Award Processes and Management
(2019-08)Research Administration is a huge endeavor with several processes to manage and many regulations to follow. A common challenge with research administration is the broad scope of work required to maintain compliance and ... -
Smoke and Mirrors: The Unintended Public Safety Effects of Marijuana Legalization
(2019-08)Existing research on the indirect societal impacts of marijuana legalization is piecemeal and tends to under-emphasize the strains placed on the public safety apparatus as a result of increased access and availability to ... -
Enabling Automation in Clinical Research Administration through Good Data Management
(2018-12)The amount of clinical trials moving through the clinical trial lifecycle pipeline continues to increase every year. From 2000 to 2013, the number of registered clinical trials increased by two orders of magnitude. Also ... -
Equivalency Analysis of State-Level Air Pollution Emissions Estimates from an Integrated Assessment Model: GCAM-USA
(2019-08)The use of Integrated Assessment Models (IAMs) has expanded from their primary application, global climate assessment, to examine broader environmental trends such as air pollution emissions, including those at sub-national ...
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