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The writing, reading and chromatin signatures of histone H3K23 on mammalian chromatin
(Johns Hopkins UniversityUSA, 2022-10-28)The DNA of eukaryotes is wrapped around histone proteins to form the nucleosome, the fundamental repeating unit of chromatin. Post-translational modifications (PTMs) on histone proteins can act to regulate chromatin ... -
Using Nanopore Sequencing to Interrogate the Genome and Epigenome
(Johns Hopkins UniversityUSA, 2022-10-17)This work involves using native RNA nanopore sequencing to directly characterize the transcriptome of a human cell line, GM12878. We demonstrated several new methods, and findings, including newly discovered isoforms, ... -
QUANTITATIVE AND QUALITATIVE CHARACTERIZATION OF THE LATENT RESERVOIR IN PEOPLE LIVING WITH HIV-1 AND NON-HUMAN PRIMATES INFECTED WITH SIMIAN-HUMAN IMMUNODEFICIENCY VIRUS (SHIV)
(Johns Hopkins UniversityUSA, 2022-10-07)Present-day combination antiretroviral treatment (cART) is highly effective in blocking Human Immunodeficiency Virus-1 (HIV-1) replication and can prevent HIV-1-infected individuals from progressing to acquired immunodeficiency ... -
PLK4 DRIVES CENTRIOLE AMPLIFICATION AND APICAL SURFACE AREA EXPANSION IN MULTICILIATED CELLS
(Johns Hopkins UniversityUSA, 2022-10-05)Multiciliated cells (MCCs) are terminally differentiated epithelia that assemble multiple motile cilia used to promote fluid flow. To template these cilia, MCCs dramatically expand their centriole content during a process ... -
MYOSIN II ASSEMBLY REGULATION THROUGH THE MYOSIN PHOSPHATASE TARGETING SUBUNIT 1 DETERMINES CORTICAL MECHANICS FUNCTION ACCORDING TO MYOSIN ASSEMBLY AND MECHANORESPONSE POTENTIAL IN PANCREATIC CANCER CELLS
(Johns Hopkins UniversityUSA, 2022-10-03)Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers as the fourth leading cause of cancer related deaths with a 5-year survival rate of 10.8%. A critical need is to develop new PDAC-specific ...
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