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THE EFFECT OF MIR-29 AND TGFB ON FIBROSIS
(Johns Hopkins UniversityUSA, 2018-09-04)Fibrosis is defined as excess accumulation of extra cellular matrix (ECM) that impedes normal function of the parenchyma and is the cause of up to 45% of deaths in the developed world. With no favorable therapeutic strategy, ... -
Risk of Aminoglycoside-Induced Hearing Loss among Patients with Drug-Resistant Tuberculosis in South Africa
(Johns Hopkins UniversityUSA, 2018-11-27)Problem Statement Individuals treated for multidrug-resistant tuberculosis (MDR-TB) with aminoglycosides (AGs) in resource-limited settings often experience permanent hearing loss, but there is no practical, cost-effective ... -
THE FORMATION OF NONSTATE ARMED GROUPS’ SOCIAL CONTRACTS IN FRAGILE STATES: THE SUDANESE LIBERATION MOVEMENT/ARMY (SLM/A) IN SUDAN AND THE UNION FOR DEMOCRATIC FORCES FOR UNITY (UFDR) IN THE CENTRAL AFRICAN REPUBLIC
(Johns Hopkins UniversityUSA, 2018-11-27)While insurgency-related literature acknowledges that nonstate social contracts occur, a microlevel analysis is needed of how this process occurs. At the same time, understanding the NSAG’s social contract in a vacuum ... -
Towards Programming Matter with Chemical Computers
(Johns Hopkins UniversityUSA, 2018-11-05)In this work, we briefly outline a paradigm for programming the growth and function of physical materials, using chemical computers implemented with DNA. We review experimental studies that enable physical stimuli, such ... -
PROTEIN ENGINEERING IMPROVEMENTS TO ENZYME/PRODRUG THERAPY USING YEAST CYTOSINE DEAMINASE
(Johns Hopkins UniversityUSA, 2018-10-26)Gene-directed enzyme prodrug therapy (GDEPT) is a two-step process whereby the gene encoding a prodrug-converting enzyme is selectively delivered to tumor cells, followed by systemic administration of a nontoxic prodrug. ...
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